A Peripherally Restricted Cannabinoid-1 Receptor Inverse Agonist Promotes Insulin Secretion and Protects from Cytokine Toxicity in Human Pancreatic Islets

The authors showed that a peripherally restricted CB1R inverse agonist, MRI-1891, augments glucose stimulated insulin secretion in isolated human pancreatic islets and mouse islets.

[European Journal of Pharmacology]

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