Solved Now that you have determined how an endocannabinoid

Now that you have determined how an endocannabinoid such as ENDO1 can induce breast cancer via the signaling pathway in Figure 4, we’re ready to evaluate potential treatments for breast cancer that occurs via disruptions in the signaling pathway in Figure 4.

The drug company you work for has asked you to evaluate two related cannabinoid molecules that could help treat breast cancer. Since 1975, researchers have been aware that cannabinoids can significantly inhibit tumor growth. More recently it was found that phytocannabinoids (cannabinoids produced by plants) are toxic to cancer cells because they interact with the human endocannabinoid system, upregulating immune responses that protect the body from the development/progression of cancer cells. Your company has identified two phytocannabinoids, CBD1 and CBD2, that they would like you to evaluate as potential treatment for breast cancer.

The following experiment was conducted to evaluate these molecules. Ten genetically identical cells were collected from cancerous breast tissue. The relative activity (% of observed max) of cell division and cell death were measured in these cancerous cells while ENDO1 was present. Then, the cells were separately exposed to two phytocannabinoids, CBD1 and CBD2, and the measurements were repeated after each exposure.

The results of these experiments are shown below.

Figure 5. The relative activity of cell division and cell death in the absence or presence of CBD1. The plots depict activities of cell division and cell death (left to right). Activity scales from 0% to 100%. To make the data easier to see, a break in the y-axis omits the range of values between 25% and 70%.
Figure 6. The relative activity of cell division and cell death in the absence or presence of CBD2. The plots depict activities of cell division and cell death (left to right). Activity scales from 0% to 100%. To make the data easier to see, a break in the y-axis omits the range of values between 25% and 70 (left plot) and 25% and 60% (right plot).

Using the data in Figure 5 and Figure 6, evaluate the two potential treatments for breast cancer and recommend which one would be a better treatment. Be sure to provide your reasoning, highlighting the relevant evidence supporting your claim. We recommend that you reread the background at the beginning of this assignment before you answer the following questions.

15. Construct a claim that answers the question “Which molecule, CBD1 or CBD2, is a better treatment for breast cancer caused by disruptions to the signaling pathway in Figure 4 by ENDO1?”

16. What evidence in Figure 5 supports your claim in Question 15?

17. What evidence in Figure 6 supports your claim in Question 15?

18. Put it all together: Why, from a biological perspective, did you recommend one molecule over the other in Question 15? Your answer should minimally explain (1) what the ideal treatment would look like and (2) connect the evidence in Figure 5 and Figure 6 to your claim in Question 15.

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