An observational study of safety and clinical outcome measures across patient groups in the United Kingdom Medical Cannabis Registry


Background:

There is a paucity of high-quality data on patient outcomes and safety after initiating treatment with cannabis-based medicinal products (CBMPs). The aim of this study was to assess the clinical outcomes and safety of CBMPs by analyzing patient-reported outcome measures and adverse events across a broad spectrum of chronic conditions.


Research design and methods:

This study analyzed patients enrolled in the UK Medical Cannabis Registry. Participants completed the EQ-5D-5L to assess health-related quality of life, Generalized Anxiety Disorder-7 (GAD-7) questionnaire to measure anxiety severity, and the Single-item Sleep Quality Scale (SQS) to rate sleep quality at baseline and follow-up after 1, 3, 6, and 12 months.


Results:

2833 participants met inclusion criteria. The EQ-5D-5L index value, GAD-7, and SQS all improved at each follow-up (p<0.001). There was no difference in EQ-5D-5L index values between former or current illicit cannabis consumers and naïve patients (p>0.050). Adverse events were reported by 474 (16.73%) participants.


Conclusions:

: This study suggests that CBMPs are associated with an improvement in health-related quality of life in UK patients with chronic diseases. Treatment was tolerated well by most participants, but adverse events were more common in female and cannabis-naïve patients.


Keywords:

CBMPs; Cannabidiol; Cannabis-based medicinal products; Medical Cannabis; Tetrahydrocannabinol.

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