Medicinal cannabis products for the treatment of acute pain


. 2023 Apr 26;11(12):2670-2676.

doi: 10.12998/wjcc.v11.i12.2670.


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Marco Fiore et al.

World J Clin Cases.



For thousands of years, medicinal cannabis has been used for pain treatment, but its use for pain management is still controversial. Meta-analysis of the literature has shown contrasting results on the addition of cannabinoids to opioids compared with placebo/other active agents to reduce pain. Clinical studies are mainly focused on medicinal cannabis use in chronic pain management, for which the analgesic effect has been proven in many studies. This review focuses on the potential use of medical cannabis for acute pain management in preclinical studies, studies on healthy subjects and the few pioneering studies in the clinical setting.


2-arachidonoylglycerol; Acute pain; Analgesia; Anandamide; Cannabinoids; Cannabis; Endocannabinoid system.

Conflict of interest statement

Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.

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