Study champions CBD with THC for insomnia

Growing consumer interest in cannabidiol (CBD) products being utilised by those suffering from insomnia is supported by past studies​ concluding there can be benefits found in CBD contribution towards positive sleep patterns.

In a new study​, the effect of Medicinal cannabis on adults with insomnia explored cannabidiol (CBD) isolate and tetrahydrocannabinol (THC) in combination. The objective of the research was to determine how well various CBD and melatonin combinations affected sleep, concluding that “Data implied that low-dose CBD use over time is safe and may enhance sleep quality.”

The authors note: “To our knowledge, our trial is the first to include midnight melatonin levels to assess the effect of medicinal cannabis oil on sleep quality in adults with insomnia, which provided a useful objective outcome measure to be included in any future trials assessing the effectiveness of medicinal cannabis on sleep.”

The study

In the ​randomised double-blind placebo-controlled crossover study, 29 participants were randomly allocated to receive placebo or Entoura 10:15 medicinal cannabis oil containing 10 mg/ml tetrahydrocannabinol (THC) and 15 mg/ml cannabidiol (CBD) over 2-weeks, followed by a 1-week wash-out period before crossover. Results were attained by saliva night time melatonin levels, validated questionnaires and Fitbit activity.

The resulting data suggests over the course of two weeks, the active group’s insomnia symptoms decreased compared to the placebo group. The active group’s total amount of sleep increased, averaging 30 minutes per night more than pre-study, compared to the placebo group’s average increase of nine minutes per night. Midnight melatonin levels significantly improved in the active group by 30% compared to a 20% decline in the placebo group (p​ = 0.035).

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